Organic Chemistry 2
Second-semester organic chemistry: aromatic chemistry, full carbonyl/acyl chemistry, enolate condensations, amines, biomolecules, advanced spectroscopy, and multi-step retrosynthesis. AP-equivalent rigor with a 1–5 score predictor.
Course Overview
This Organic Chemistry 2 course on Study Mondo covers 17 topics organized across 6 categories. Each topic includes detailed written explanations, worked examples, practice problems with step-by-step solutions, flashcards for review, and interactive lessons to help you master the material.
What You'll Learn
Conjugation, Pericyclic & Aromatic Chemistry
Conjugated dienes, Diels-Alder pericyclic reactions, aromaticity, EAS, NAS, phenol/quinone chemistry
Carbonyl Chemistry: Aldehydes, Ketones & Acyl Substitution
Nucleophilic addition, organometallic reagents, reduction/oxidation, nucleophilic acyl substitution at carboxylic acid derivatives
Enolates & Carbonyl α-Substitution
Enol/enolate formation, alpha-halogenation/alkylation, aldol & Claisen condensations, Michael additions, Robinson annulation
Amines & Heterocyclic Nitrogen Chemistry
Amine basicity & synthesis, Hofmann elimination, diazonium chemistry, intro to heterocycles
Biomolecules
Carbohydrates, amino acids/peptides/proteins, lipids and nucleic acids — through an organic-mechanism lens
Advanced Spectroscopy & Multi-Step Synthesis
Advanced 2D NMR (COSY, HSQC, HMBC), structure elucidation, retrosynthetic analysis, multi-step total synthesis
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Diagnostic across all Organic Chemistry 2 topics: aromatics, full carbonyl chemistry, enolates, biomolecules, advanced NMR, retrosynthesis.
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Conjugated dienes, Diels-Alder pericyclic reactions, aromaticity, EAS, NAS, phenol/quinone chemistry
Conjugated Systems & Dienes
Conjugation, 1,2- vs 1,4-addition, Diels-Alder reaction, MO theory, and UV-Vis spectroscopy
Aromatic Compounds & Benzene
Aromaticity, Hückel's rule, benzene structure, nomenclature, and aromatic vs antiaromatic
Electrophilic Aromatic Substitution
EAS mechanism, halogenation, nitration, Friedel-Crafts, directing effects, and multi-step synthesis
Pericyclic Reactions & the Diels-Alder
Frontier molecular orbital analysis, [4+2] cycloadditions, endo selectivity, electrocyclic reactions, and sigmatropic rearrangements
Nucleophilic Aromatic Substitution
SNAr addition-elimination through the Meisenheimer complex, benzyne mechanism, and substituent effects
Phenols & Quinones
Phenol acidity, oxidation to quinones, redox biology, antioxidants, and Kolbe-Schmitt synthesis
Nucleophilic addition, organometallic reagents, reduction/oxidation, nucleophilic acyl substitution at carboxylic acid derivatives
Enol/enolate formation, alpha-halogenation/alkylation, aldol & Claisen condensations, Michael additions, Robinson annulation
Enolate Chemistry
Keto-enol tautomerism, enolate formation, aldol reaction, Claisen condensation, Michael, and Robinson reactions
Aldol & Claisen Condensations
Crossed and intramolecular aldol reactions, Claisen and Dieckmann condensations, directed enolates with LDA
Michael Addition & Robinson Annulation
Conjugate (1,4) addition to α,β-unsaturated carbonyls, soft vs hard nucleophiles, and the Robinson annulation ring-forming sequence
Amine basicity & synthesis, Hofmann elimination, diazonium chemistry, intro to heterocycles
Carbohydrates, amino acids/peptides/proteins, lipids and nucleic acids — through an organic-mechanism lens
Carbohydrates
Monosaccharide structure, Fischer/Haworth projections, disaccharides, and polysaccharides
Amino Acids & Proteins
Amino acid structure, acid-base properties, peptide bonds, protein structure levels, and reactions
Lipids & Nucleic Acids
Fatty acids, triglycerides, phospholipids, terpenes, steroids, nucleotides, and DNA/RNA
Advanced 2D NMR (COSY, HSQC, HMBC), structure elucidation, retrosynthetic analysis, multi-step total synthesis