Enolates & Carbonyl α-Substitution

Enol/enolate formation, alpha-halogenation/alkylation, aldol & Claisen condensations, Michael additions, Robinson annulation

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Topics Covered

• Enolate Chemistry — Keto-enol tautomerism, enolate formation, aldol reaction, Claisen condensation, Michael, and Robinson reactions
• Aldol & Claisen Condensations — Crossed and intramolecular aldol reactions, Claisen and Dieckmann condensations, directed enolates with LDA
• Michael Addition & Robinson Annulation — Conjugate (1,4) addition to α,β-unsaturated carbonyls, soft vs hard nucleophiles, and the Robinson annulation ring-forming sequence

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