Biochemistry Foundations
Amino acids, enzyme kinetics, metabolism, lipids, nucleic acids, and bioenergetics
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📂 Subtopics in Biochemistry Foundations
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Amino Acids & Proteins
Structures, properties, and protein organization levels
2→
Enzymes & Kinetics
Michaelis-Menten behavior and inhibition models
3→
Carbohydrate Metabolism
Glycolysis, gluconeogenesis, and glycogen pathways
4→
Lipid Metabolism
Fatty acid oxidation, synthesis, and ketone body basics
5→
Bioenergetics & ETC
Krebs cycle, electron transport chain, and ATP accounting
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Biochemistry Foundations for the MCAT
Amino Acids & Protein Structure
20 standard amino acids classified by side chain:
- Nonpolar: G, A, V, L, I, P, F, W, M
- Polar: S, T, C, Y, N, Q
- Positively charged: K, R, H
- Negatively charged: D, E
Protein Structure:
- Primary: amino acid sequence
- Secondary: α-helix, β-sheet (H-bonds)
- Tertiary: 3D fold (hydrophobic, ionic, disulfide)
- Quaternary: multiple subunits
Enzyme Kinetics
- Competitive inhibitor: Increases apparent Km, Vmax unchanged
- Non-competitive inhibitor: Decreases Vmax, Km unchanged
Metabolism
- Glycolysis: Glucose → 2 pyruvate + 2 ATP + 2 NADH (cytoplasm)
- Krebs Cycle: Acetyl-CoA → 2 CO₂ + 3 NADH + 1 FADH₂ + 1 GTP
- ETC/Oxidative Phosphorylation: NADH → ~2.5 ATP; FADH₂ → ~1.5 ATP
- Total from glucose: ~30-32 ATP
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Amino acids, enzyme kinetics, metabolism, lipids, nucleic acids, and bioenergetics
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